STRmix™. Resolve more DNA mixtures

STRmix™ is expert forensic software that can resolve previously unresolvable mixed DNA profiles. Developed by global leaders in the field, it uses a fully continuous approach for DNA profile interpretation, resolving complex DNA mixtures worldwide.


STRmix™ interprets complex DNA results in minutes.


STRmix™ software runs on a user's PC, without the need for high-speed computing.


STRmix™ can easily be understood and explained in court by DNA analysts.

Click here for a short animated video overview of STRmix:

To download the latest STRmix™ brochure click here

STRmix™ is a breakthrough for forensic analysts as it can assist investigations using DNA evidence that was previously considered too complex to interpret. The software has been developed by New Zealand Crown research institute ESR, with Forensic Science South Australia (FSSA).  STRmix™’s quality management system is certified to AS/NZS ISO 9001:2015 by Telarc.  To view the certificate, please click here [PDF, 387 KB].

STRmix™ includes a function that allows the software to match mixed DNA profiles directly against a database. This is a major advance for cases where there are no suspects and there is DNA from multiple contributors in one sample.

With STRmix™ you will be able to:

  • interpret DNA results faster
  • combine DNA profiles from different kits in the same interpretation
  • compare profiles against a person of interest and calculate a likelihood ratio (LR)
  • resolve previously unresolvable, complex DNA mixtures with no restriction on the number of contributors
  • use more of the information in a DNA profile, and model any type of stutter 
  • search complex, mixed DNA profiles against a database.
Defence Access (updated April 2020):  Information on access to STRmix™ software by defence legal teams can be found here [PDF, 750 KB].  To access the STRmix™ Non-Disclosure and Confidentiality Agreement (Abbreviated NDA) click here [PDF, 208 KB].  To access the STRmix™ Non-Disclosure and Confidentiality Agreement (Full NDA) click here [PDF, 284 KB].  To access the STRmix™ 60 Day Defense Access Software License Agreement click here [PDF, 305 KB].


Copyright and disclaimer can be found here [PDF, 85 KB].

Privacy statement can be found here [PDF, 603 KB].

STRmix™ V2.7 is now available for purchase. Join our database for updates or contact us to request a quote.



Resolve mixed DNA profiles  without reference to known contributors.

Enter contributor number range when performing a deconvolution.

Assign an LR varying the number of contributors under the prosecution and defence propositions

Undertake quality checks for data.

Model any type of stutter observed within your STR profiling kit.

Compare reference DNA profiles to single source and mixed DNA profiles and provide a statistical weighting.

Interpret DNA profiling data generated by any autosomal STR profiling kit.

Interpret DNA profiles from a range of starting template DNA concentrations.

Use laboratory-specific settings to perform calculations suited exactly to that laboratory’s results.

Search a deconvoluted DNA profile directly against a database without the need to interpret a single source component.

Compare mixtures to other mixtures to find common contributors.

Calculate multiple LRs from multiple reference inputs to a previously run deconvolution (LR Batch tool).

Perform a large number of in-silico specificity tests on a profile-by-profile basis (Hd True Tester tool).

Batch multiple deconvolutions or other STRmix™ functions (such as interpretation, LR from Previous, and Database Search) in a queue, allowing the user to run multiple deconvolutions and calculate LRs sequentially.

Combine multiple amplifications of the same DNA extract - even when generated with different multiplexes - into one interpretation.

Accommodate data generated by protocols demonstrating increased stochastic variation and non-zero allelic drop-in rates, for example elevated PCR cycle number and enhanced CE injection methods.

Include related individuals as alternate propositions in the LR.

Carry out familial searches against a database, searching for close relatives of contributors to mixed DNA profiles.

Generate fully configurable (and if required, retrospective) reports including a CODIS report. 

Password protect default settings and kit settings.


STRmix™ has already been used for routine casework interpretation at ESR and FSSA since August 2012 and is now the Australasian standard for DNA interpretation.

In one case, a mixed DNA profile was obtained from a semen stain on a carpet at the scene of an alleged sexual assault involving two male offenders. DNA from two individuals was detected, present in approximately equal proportions (see EPG below). This profile was unsuitable for database searching using traditional DNA interpretation methods. Using STRmix™, the profile was interpreted assuming two contributors and compared against a database with over 145,000 profiles. The crime profile matched two individuals.

This case highlights how STRmix™'s database search function can provide investigative information. It can also be used to validate complex mixtures where contamination is suspected.

STRmix™ V2.7 is now available for purchase. Join our database for updates or contact us to request a quote.

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STRmix™ combines biological modelling and mathematical processes to interpret a wide range of complex DNA profiles. 

Using well-established statistical methods, the software builds millions of conceptual DNA profiles.  It grades them against the evidential sample, finding the combinations that best explain the profile.  A range of Likelihood Ratio options are provided for subsequent comparisons to reference profiles.

Using a Markov Chain Monte Carlo engine, STRmix™ models any types of allelic and stutter peak heights as well as drop-in and drop out behaviour.  It does this rapidly, accessing evidential information previously out of reach with traditional methods.   

STRmix™ is supported by comprehensive empirical studies with its mathematics readily accessible to DNA analysts, so results are easily explained in court.


STRmix™ has been extensively validated and has been used for casework interpretation at ESR and multiple Australian, US, Middle East, Europe and UK laboratories (first implemented in August 2012).  STRmix™ has achieved Certificate of Networthiness (CoN) status on the United States Army Network.


Papers describing the biological model, mathematics, performance and validation of STRmix™ have been published:

[1] D.A. Taylor, J.-A. Bright, J. S. Buckleton, The interpretation of single source and mixed DNA profiles, Forensic Science International: Genetics. 7(5) (2013) 516-528.

[2] J.-A. Bright, D.A. Taylor, J. M. Curran, J. S. Buckleton, Developing allelic and stutter peak height models for a continuous method of DNA interpretation, Forensic Science International: Genetics. 7(2) (2013) 296-304.

[3] J.-A. Bright, D.A. Taylor, J. Curran, J.S. Buckleton, Degradation of forensic DNA profiles, Australian Journal of Forensic Sciences. 45(4) (2013) 445-449.

[4] J.-A. Bright, D.A. Taylor, J. M. Curran, J. S. Buckleton, Searching mixed DNA profiles directly against profile databases Forensic Science International: Genetics. 9 (2014) 102-110.

[5] D.A. Taylor. Using continuous DNA interpretation methods to revisit likelihood ratio behaviour. Forensic Science International: Genetics, 2014. 11: 144-153.

[6] J.-A. Bright, J.M. Curran and J.S. Buckleton, The effect of the uncertainty in the number of contributors to mixed DNA profiles on profile interpretation. Forensic Science International: Genetics, 2014. 12: 208-214.

[7] J.-A. Bright, I.W. Evett, D.A. Taylor, J.M. Curran and J.S. Buckleton, A series of recommended tests when validating probabilistic DNA profile interpretation software. Forensic Science International: Genetics, 2015. 14: 125-131.

[8] J.-A. Bright, K.E. Stevenson, J.M. Curran and J.S. Buckleton, The variability in likelihood ratios due to different mechanisms. Forensic Science International: Genetics, 2015. 14:187-190.

[9] D.A. Taylor, J.-A. Bright and J.S. Buckleton, Considering relatives when assessing the evidential strength of mixed DNA profiles. Forensic Science International: Genetics, 2014. 13: 259-263.

[10] T.W. Bille, S.M. Weitz, M.D. Coble, J.S. Buckleton and J.-A. Bright, Comparison of the performance of different models for the interpretation of low level mixed DNA profiles. Electrophoresis, 2014. 35:3125-33.

[11] D.A. Taylor, J.-A. Bright and J.S. Buckleton, The ‘factor of two’ issue in mixed DNA profiles. Journal of Theoretical Biology, 2014. 363: p. 300-306.

[12] D.A. Taylor and J.S. Buckleton, Do low template DNA profiles have useful quantitative data? Forensic Science International: Genetics, 2015. 16:13-6.

[13] D.A. Taylor, J.S. Buckleton and I. Evett, Testing likelihood ratios produced from complex DNA profiles. Forensic Science International: Genetics, 2015. 16:165-171.



[14] S.J. Cooper, C.E. McGovern, J.-A. Bright, D.A. Taylor and J.S. Buckleton, Investigating a common approach to DNA profile interpretation using probabilistic software. Forensic Science International: Genetics, 2015. 16:121-131.

[15] J.-A. Bright, D.A. Taylor, C.E. McGovern, S.J. Cooper, L.J. Russell, D.V. Abarno and J.S. Buckleton, Developmental validation of STRmix™, expert software for the interpretation of forensic DNA profiles. Forensic Science International: Genetics, 2016. 23:226-239.

[16] D.A. Taylor, J.-A. Bright, C.E. McGovern, C. Hefford, T. Kalafut, J.S. Buckleton, Validating multiplexes for use in conjunction with modern interpretation strategies. Forensic Science International: Genetics, 2016.  20:6-19.

[17] D.A. Taylor, J.S. Buckleton,  J.-A. Bright, Factors affecting peak height variability for short tandem repeat data.  Forensic Science International: Genetics, 2016.  21:126-133.

[18] T.R. Moretti, R.S. Just, S.C. Kehl, L.E. Willis, J.S. Buckleton, J.-A. Bright, D.A. Taylor, Internal validation of STRmix™ for the interpretation of single source and mixed DNA profiles.  Forensic Science International: Genetics, 2017.  29:126-144.

[19] D.A. Taylor, J.-A. Bright, H. Kelly, M.-H. Lin, J.S. Buckleton.  A fully continuous system of DNA profile evidence evaluation that can utilise STR profile data produced under different conditions within a single analysis.  Forensic Science International: Genetics, 2017.  31:149-154.

[20] D.A. Taylor, J.S.  Buckleton, J.-A. Bright, Does the use of probabilistic genotyping change the way we should view sub-threshold data?  Australian Journal of Forensic Sciences, 2017.  49(1):78-92.

[21] J.-A. Bright, et al., Internal validation of STRmix; A multi laboratory response to PCAST. Forensic Science International: Genetics, 2018.  34:11-24.

[22] J.S. Buckleton, et al.,The Probabilistic Genotyping Software STRmix: Utility and Evidence for its Validity. Journal of Forensic Sciences, 2019. 64(2): 393-405.

[23] D.A. Taylor, J.-A. Bright , J.S. Buckleton, Interpreting forensic DNA profiling evidence without specifying the number of contributors. Forensic Science International: Genetics. 2014;13:269-80.

[24] D.A.Taylor, J.-A. Bright, J.S. Buckleton, J. Curran, An illustration of the effect of various sources of uncertainty on DNA likelihood ratio calculations. Forensic Science International: Genetics. 2014;11:56-63.

[25] J.-A. Bright,  K.E. Stevenson, M.D. Coble, C.R. Hill, J.M. Curran, J.S. Buckleton, Characterising the STR locus D6S1043 and examination of its effect on stutter rates. Forensic Science International: Genetics. 2014;8:20-3.


STRmix™ is designed to run on an individual DNA analyst’s PC (either standalone or in a networked environment), without the need for high speed computing.

Low spec1 Medium spec2 High spec3
Intel core 2 (Quad core) processor Intel i5, i7 2.6 GHz  Intel 2.4 GHz Xeon CPU E5 or better4
4 GB RAM 16 GB RAM 128 GB RAM or above
Minimum of 2 cores  Minimum of 4 cores  Minimum of 8 cores 
300MB free HDD space 300MB free HDD space5  300MB free HDD space5
Windows 7 or above Windows 7 Professional 64 bit or above Windows 7 Professional 64 bit or above

1 will run most 1, 2 and some 3 person mixtures, particularly in low memory mode, may also run some 4 person cases

2will run most 1, 2, 3 and 4 person mixtures, particularly in low memory mode

3will run most 1,2,3,4 person mixtures (including with replicates) and some 5 person mixtures (including with replicates)

4consult with NicheVision/ESR on particular models if concerned. 

5this is the space required for the application itself and does not include the space required for results of STRmix™ runs.


Windows Vista 64-bit Service Pack 1, Windows 7 64-bit Service Pack 1, Windows 8.1 64-bit, Windows 10 64-bit.

STRmix™ V2.7 is now available for purchase. Join our database for updates or contact us to request a quote.

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DBLR 890w

From the team that brought you STRmix™.  DBLR™ (database likelihood ratios) is an application designed for the rapid calculation of likelihood ratios (LRs) using STRmix™ deconvolutions.



DBLR™ calculates millions of LRs in seconds.


DBLR™ runs on a user’s PC, without the need for high-speed computing.


DBLR™ enables you to get more value from your DNA evidence.

For a short walk-through of the functions in DBLR™ please click here:


  • Achieve superfast database searches.
  • Visualise the value of your DNA mixture evidence.
  • Undertake mixture to mixture matches.


  • Undertake direct comparison of one or many components of a forensic DNA mixture to a database of known individuals (i.e. “Who contributed to the profile?”).
  • Carry out familial searching for a range of different relationships including siblings, half-siblings, parents, and children (i.e. “Is there a relative of the donor in the database?”).
  • Search for common contributors between mixed DNA profiles (mixture to mixture comparisons).
  • Determine the profiles of the most likely contributors to a profile.
  • Visualise the value of evidence by calculating expected LRs for one or many components of forensic DNA profiles for true and non-contributors using randomly generated individuals.
  • Manage automated searches for one or many DNA profiles against one or many databases of known individuals.
  • Manage databases of known contributors and STRmix™ deconvolutions from unsolved casework for easy matching.


DBLR™ uses efficient algorithms for the fast calculation of LRs.  To see an example of use of DBLR™ with STRmix™, please click here


DBLR™ has been extensively validated by the STRmix™ team based at ESR, New Zealand.


DBLR™ is designed to run on an individual DNA analyst’s PC.


Using DBLR we can explore the interpretation results from a DNA profile given different hypotheses.  We calculate thousands of likelihood ratios and by plotting these we can see the expected range for the different hypotheses.  This can quickly help inform whether the profile is suitable for comparison with a person of interest or if it is suitable for entry onto a database for matching.

To see more, please click here:


The following papers describe the mathematics and application of DBLR™:

[1] Slooten K. Identifying common donors in DNA mixtures, with applications to database searches. Forensic Science International: Genetics.2017;26:40-7.

[2] Kruijver M, Bright J-A, Kelly H, Buckleton J. Exploring the probative value of mixed DNA profiles. Forensic Science International: Genetics. 2019 2019;41: 1-10.

[3] Bright J-A, Taylor D, Kerr Z, Buckleton J, Kruijver M. The efficacy of DNA mixture to mixture matching. Forensic Science International: Genetics. 2019;41: 64-71.

[4] Taylor D, Rowe E, Kruijver M, Abarno D, Bright J-A, Buckleton J. Inter-sample contamination detection using mixture deconvolution comparison. Forensic Science International: Genetics. 2019: 160-167.

To download the latest DBLR™ brochure click here  

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who developed strmix

Institute of Environmental Science and Research (ESR)

ESR is New Zealand’s Crown Research Institute specialising in science for communities.  ESR uses world-leading science to safeguard our health, keep our communities safer, protect our food-based economy, and improve the health of our water and natural environment.

Forensic Science South Australia (FSSA)

FSSA provides services to some of South Australia’s largest government departments and undertakes award-winning research in forensic science.


STRmix Limited

STRmix Limited is a subsidiary of ESR, founded to better serve international users of STRmix™.

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Subscribe to the news

Re-scheduled: STRmix USA Workshop, Boston, MA, 8-11 February 2021

Friday, 29 May 2020

Improving DNA Typing, by Dr Bruce Budowle, Blue Line Magazine

Friday, 29 May 2020

STRmix™ Now Being Used by Suffolk County Crime Lab, Contra Costa Sheriff’s Office

Friday, 29 May 2020

Colorado Court Affirms Use of Evidence Generated by STRmix™

Friday, 29 May 2020

Colorado Court Rules STRmix™ Is “Relevant and Reliable” Practice for Interpreting Likelihood Ratios

Tuesday, 12 May 2020

Indiana Court of Appeals Affirms Murder Conviction, Use of DNA Evidence Produced by STRmix™

Monday, 30 March 2020

STRmix™ Co-Developer John Buckleton Honored

Wednesday, 18 March 2020

Wisconsin, Louisiana Forensic Labs Now Using STRmix™

Wednesday, 18 March 2020

Postponed - STRmix USA Workshop, Largo, FL

Tuesday, 18 February 2020

NY District Court Rules Denies Defendant’s Motion to Preclude STRmix™ Testimony

Tuesday, 18 February 2020

STRmix™ Quality Management System Achieves ISO9001:2015 Certification

Friday, 31 January 2020

STRmix™ Will Be Used in San Antonio, Golden, and Tucson Forensic Labs

Friday, 31 January 2020

ESR commentary on California vs. Dominguez

Tuesday, 10 December 2019

Forensic Labs in Houston, NorthEastern Illinois will use STRmix™

Tuesday, 10 December 2019

STRmix™ updates Defense Access Policy

Friday, 1 November 2019

STRmix v2.7 Released, Featuring Improvements in Resolving Profiles, Input Quality Checks

Wednesday, 11 September 2019

STRmix™ in the News: How police techniques, old and new, captured the killer of a Guelph hotel manager

Wednesday, 4 September 2019

Use of STRmix™ Expands in Universities

Wednesday, 4 September 2019

Survey Shows STRmix™ Used in More Than 120,000 Cases Worldwide

Tuesday, 20 August 2019

Technical report: An explanation of Figure 13 from Bright et al. Internal validation of STRmix™ – A multi laboratory response to PCAST

Tuesday, 30 July 2019

Sneak preview of STRmix™ v2.7

Tuesday, 23 July 2019

Technical report: Experiments on the number of contributors, two fewer and two more

Tuesday, 23 July 2019

Announcing STRmix™ v2.7

Friday, 21 June 2019

DBLR™ discussion with Dr Maarten Kruijver

Friday, 5 April 2019

Want to know more about DBLR™?

Tuesday, 26 February 2019

Coming soon from STRmix™: DBLR™ database search tool

Friday, 15 February 2019

STRmix™ in the news: MI Authorities Employ New DNA Analysis Software

Tuesday, 5 February 2019

With Five New Additions , STRmix™ Now Being Used in 43 Labs Nationwide

Monday, 4 February 2019

STRmix™ in the news: STRmix™ Use Leads to Indiana Murder Conviction

Monday, 17 September 2018

Recent STRmix™ news

Tuesday, 11 September 2018

STRmix™ in the news: New software can do what no human could, helps state police analyze DNA evidence

Friday, 6 July 2018

Sneak preview of STRmix™ v2.6

Monday, 25 June 2018

Information regarding DNA results in the Haruka Weiser murder case (Texas)

Friday, 22 June 2018

STRmix™ in the news: Montreal forensics lab approves STRmix™ use

Tuesday, 5 June 2018

The treatment of uncertainty in STRmix™

Wednesday, 30 May 2018

STRmix™ v2.6 is coming!

Wednesday, 23 May 2018

Summary of miscodes

Wednesday, 23 May 2018

STRmix™ in the news: Crime-Busting Forensic Software STRmix™ Triumphs in U.S. Murder Trial

Monday, 21 May 2018

STRmix™ in the news: Houston-based Forensic Lab Approves Mixed DNA Profile Forensic Software

Monday, 21 May 2018

In Press: A sensitivity analysis to determine the robustness of STRmix™ with respect to laboratory calibration

Monday, 30 April 2018

DNA’s Newfound Power for Crime-Solving

Tuesday, 10 April 2018

STRmix™ in the news: New Mexico Case Allows Expert Testimony, Affirms STRmix™ Reliability

Monday, 9 April 2018

DNA Software in the Courts and the Future

Monday, 9 April 2018

STRmix™ in the news: DNA technology used to link convicted killer to another murder victim wasn’t available in 2009

Monday, 12 February 2018

STRmix™ in the news: How new DNA technology led to Jupiter triple homicide arrests

Monday, 5 February 2018

Published in FSI: Genetics: Internal validation of STRmix™ – A multi laboratory response to PCAST

Friday, 19 January 2018

Minnesota Court Rules STRmix™ Use Is Admissible

Friday, 5 January 2018

STRmix™ Used in Brooklyn Murder Case

Sunday, 24 December 2017

STRmix™ Celebrates Fifth Anniversary of Live Casework Use

Monday, 6 November 2017

STRmix™ in the news: Eight More Agencies, Including ATF, Will Use STRmix™

Friday, 29 September 2017

Ruling – the People of the State of New York versus Oral Nicholas Hillary (NY) - DNA evidence admissibility

Tuesday, 12 September 2017

Harris County Institute of Forensic Sciences DNA analysts receive onsite STRmix™ training

Wednesday, 6 September 2017

Description of the likelihood ratio (LR) changes in STRmix™ v2.4.08

Wednesday, 23 August 2017

Update on STRmix™ research in response to PCAST

Friday, 18 August 2017

STRmix™ evidence admitted in UK case

Monday, 7 August 2017

STRmix™ admissibility granted in Michigan Daubert hearing

Monday, 7 August 2017

See STRmix™ v2.5 in action here

Friday, 28 July 2017

Two more cases affirm use, reliability of STRmix™

Friday, 28 July 2017

How Forensic DNA Software Passes the Daubert Standard

Friday, 9 June 2017

STRmix™ in the news: FL Murder Case Reaffirms Reliability of STRmix™

Friday, 2 June 2017

STRmix™ v2.5 is coming!

Monday, 29 May 2017

FBI validates STRmix™ for use on up to five-person mixtures

Tuesday, 23 May 2017

Three More U.S. Labs Now Using STRmix™

Thursday, 13 April 2017

Green Mountain DNA Conference Presentation, August 2016 - Probabilistic Genotyping and the Bench Scientist – Using STRmix in Everyday Casework, T Kalafut

Thursday, 13 October 2016

STRmix comments on the PCAST Report to the President Forensic Science in Criminal Courts: Ensuring Scientific Validity of Feature-Comparison Methods, September, 2016

Friday, 7 October 2016

STRmix update, October 3rd 2016

Monday, 3 October 2016

Did you know?

Tuesday, 28 June 2016

Key Forensic Services Limited achieves accreditation for STRmix™

Wednesday, 15 June 2016

STRmix™ developmental validation article accepted in Forensic Science International: Genetics

Monday, 16 May 2016

STRmix™ attends ENFSI DNA 2016

Friday, 29 April 2016

STRmix™ in the news: Lost shoe led to landmark DNA ruling - and now, nation's 1st guilty verdict

Friday, 29 April 2016

Access to STRmix™ Software by Defence Legal teams

Thursday, 28 April 2016

STRmix™ in the news: DNA breakthrough: North Adelaide rape suspect arrested

Thursday, 21 April 2016

Misrepresentation of STRmix by Mr Dominic Saraceno ESQ in People of New York v. David Smith

Wednesday, 20 April 2016

Statement on minor miscoding in BN formulae in STRmix v1.08

Wednesday, 20 April 2016

STRmix™ version 2.4 released 7 April 2016

Friday, 8 April 2016

Statement relating to STRmix™ miscodes

Friday, 18 March 2016

NIST Inter Laboratory Study 2013

Friday, 24 July 2015

STRmix™ runs for charity

Thursday, 19 March 2015

STRmix™ version 2.3 released 1st February 2015

Monday, 2 February 2015

View the recent "Mixture Monday" web meeting: Discuss Probabilistic Software with John Buckleton

Wednesday, 17 December 2014

NIST Investigation of Probabilistic Software Programs Released

Thursday, 27 November 2014

NicheVision Forensics is now the exclusive STRmix™ distributor for the Americas, including the United States, Canada, Central and South America.

Monday, 6 October 2014

ESR technology being used to solve war crimes

Monday, 6 October 2014

'Dream' software boost power of DNA

Monday, 6 October 2014

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STRmix™ is expert forensic software that can resolve previously unresolvable mixed DNA profiles. Developed by world leaders in the field, it uses a fully continuous approach for DNA profile interpretation, resolving complex DNA mixtures with no restriction on the number of contributors.

For more information about STRmix™ or to request a quote:

North/South/Central America 
NicheVision Inc.
526 So Main St Ste 714-G, Akron OH 44311, USA
T:  1-866-840-3758 (US Only) or 1-330-252-2711 (International)
Vic Meles

Adam McCarthy
M:  +44(0)7590 405 501 



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